Brody, maybe I missed it, but I don't think anyone has mentioned hormone testing to see if this is a contributor to your wife's condition. I have had insomnia for decades along with progressive pain from back surgery and degenerating discs in my neck along with many old injuries coming back to say Hi.
This is just my experience, but when I started taking DHEA, I started sleeping much better. Instead of always having a 2 hour wake up period in the middle of the night, or not getting to sleep until 4 am, I now wake up briefly twice a night then go right back to sleep. My chronic pain is much reduced. I also started taking pregnenolone, which is a pro-hormone that is metabolized into DHEA, estrogens, cortisol, and testosterone, so your body converts it into what's needed, which I like. I take 20 mg of pregnenolone and I noticed within two days that I was much calmer and yet more alert - like the engine inside me wasn't constantly revving up like it has been doing my whole life. One odd benefit of taking pregnenolone is that I now have nice finger nails. The low-level agitation is gone so I'm not picking at my nails anymore.
One thing that's really interesting is that I did the elimination diet last year for food sensitivities and found many that set my heart racing. Now that I'm on the DHEA and pregnenolone, I'm not nearly as sensitive to these foods.
If your wife's hormones are out of whack, which is almost guaranteed with the level of stress she's been under, it's really difficult to get a handle on anything else. I would advise seeing a doctor that will check her hormone levels and approach it from this angle.
BTW I am a trained herbalist and although both western and Chinese herbs helped, nothing seemed to fix the underlying issue, which for me seems to be low hormone levels. If you do some searching, you'll find that low hormones can cause many of the symptoms that your wife is experiencing.
The mold you mentioned definite needs to get fixed for your health as well as hers. I used to do mold assessments in a previous job so if you want more info let me know and I can give a few pointers.