I think the key lies in the definition of the word "profitable". A relationship between mycorrhizael fungi and trees is mutually profitable. I don't think the activities of, say, Rupert Murdoch should be described using the same term. Therefore, "profitable" for that which brings good to one or multiple parties, and "exploitative" for screwing over the other guy. If I make ropes, nets and baskets and the guy next door has a permaculture farm and we trade, it would be mutually profitable.