I see no one has responded for a couple months, but I'll give it a whirl.
Up here in the PNW there are TONS of fiber farms. I don't know all of them but I am guessing that here, yes, there are people who do a mix of permaculture fiber farms. Actually, I do know one person who is doing observational permaculture and has sheep, goats, chickens, turkeys, two cows, alpacas and pigs. They are focused on being self sufficent, so the fiber they use for themselves. Yes, it can be done. You might want to concider going to the black sheep gathering in Eugene in June. There are farmers there showing their animals (and fleeces) who you could talk to...at the very least its a real blast if fiber is your thing.
People mix animals, especially llamas and alpacas into sheep herds. One or two can work as good guard animals, but too many and they form a flock of their own and don't care about the sheep.
I would say it is best done by starting with one or two species, then slowly adding new animals once you learn how those specific animals live and thrive. Really its important to really learn how your animals communicate.
When my niece got rabbits she started adding their (paper) litter to the compost. The compost suddenly was filled with grubs. If you have chickens, rabbit litter in the compost will make you alot of extra feed.
chickens and pigs can rotationally follow sheep and cows picking out undigested grain from their, uh, refuse.
I've heard of people spinning highland cattle "wool"....dont know how soft it is, but it might work as a multi-purpose breed for you
Get a hardy breed of sheep. I had Jacobs last year and they were a breeze. This year I have dairy sheep and they are ok....but not as hardy. They DEMAND GRAIN BECAUSE OMG THERE IS NOTHING ELSE TO EAT, whereas the Jacobs could still find something to eat in the winter. "Older" breeds of sheep have better ability to forage, be self sufficient and lamb without complications.
anyway, good luck.